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Viral vectors are a key technology for neuroscience research, allowing delivery of genes into the brain to manipulate brain function- viruses can be delivered with spatial and temporal specificity, and can be engineered to produce cell-type specificity of expression. Importantly, viruses can also be used for genetic manipulation of species

Viral vectors are a key technology for neuroscience research, allowing delivery of genes into the brain to manipulate brain function.

In addition to their speed and cost advantages, viruses can be delivered with spatial and temporal specificity, and in some cases can be engineered to produce cell-type specificity of expression.

The viral gene transfer core was established in 2008 by the Picower Institute and the McGovern Institute to make viral vectors accessible to the MIT neuroscience community.
Directed by Rachael Neve, its overall goals are to provide the most advanced viral vector technologies, and to drive the development of new applications that will benefit neuroscience research.

The production of viruses requires special expertise, and given the range of vectors now available, it is not easy for individual labs to develop the necessary expertise to take full advantage of these technologies. Continue reading

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